Liability is also denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties. 27 Based on in vitro studies, the relative sensitivity of species to the oxidative effect of this metabolite is: rat is more sensitive than … Use Activyl for Dogs, on dogs and puppies 8 weeks of age or older. Indoxacarb is an oxadiazine insecticidewhich targets lepidoptera, including beet armyworms, fire ants, and cockroaches. DE only kills the ants that crawl through it. Absorbed indoxacarb is extensively metabolized (>90%) in the liver to inactive metabolites. Indoxacarb shows low persistence in aquatic systems. The only drawback? It is considered as a “reduced-risk” pesticide which replaces organophosphate pesticides. It has been used against lepidopteran pests but has recently been approved for use against fleas in dogs and cats. Indoxacarb has a specific mode of action. Activyl is a spot-on topical formulation for pets with the active ingredient indoxacarb, an antiparasitic agent that helps in killing ticks, fleas as well as their eggs and larvae, breaking their life cycle, and preventing reinfestation [1, 2, 4]. Indoxacarb is considered a suitable, "low-toxicity", synthetic organophosphate replacement. Moreover, exposure to sunlight does not reduce its efficacy [7]. Indoxacarb DIY Quick Facts Quick Summary: ... products – including flea treatments and bait products – are pre-diluted to low levels and should be perfectly safe to handle if you follow the manufacturer’s instructions. Indoxacarb is an antiparasitic agent primarily used to kill adult fleas. Each ml of the medication contains 195mg of indoxacarb. Indoxacarb is a new insecticide produced by DuPont and marketed in the U.S. as StewardTM, AvauntTM and Technical IndoxacarbTM. Plastic is indigestible and can cause a blockage in your pet’s digestive tract. If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. Everyone knows there are 4 season s: winter, spring, fall, and summer.Dog owners, however, have come to learn that there’s a fifth season that is deadlier than hot summers and frozen winters. Instead of reaching its bloodstream, indoxacarb works by bioactivation, a mode of action that changes Activyl into a highly insecticidal substance once it comes in contact with the amidase and esterase enzymes in the body of the tick or flea [3, 4]. At the time of initial registration (10/2000) Indoxacarb was formulated as a 30% a.i. Is indoxacarb toxic to dogs? Indoxacarb is moderately to highly toxic to fish and invertebrates. Indoxacarb is a common ingredient in ant traps as well as various topical medications that are formulated to get rid of ticks or fleas. This safety summary is a complement to the information on product labels and MSDS. Indoxacarb is a relatively new oxadiazine insecticide. Slowly but gradually the solution spreads through the pet’s skin. They are applied to a small area of skin but soon spread on the skin and coat. Activyl spot on/tick plus for very small dogs and puppies (4-14 lb), Activyl spot on/tick plus for small dogs (14-22 lb), Activyl spot on/tick plus for medium dogs (22-44 lb), Activyl spot on/tick plus for large dogs (44-88 lb), Activyl spot on/tick plus for extra-large dogs (88-132 lb), Dogs weighing less than 4 pound and puppies under eight weeks of age, Pregnant, or nursing dogs and those meant for breeding, Temporary itchiness, hair loss, or inflammation at the application site, Drooling, vomiting, salivation, squinting, or shaking may occur if your dog licks the affected area straight after the application of Activyl, Hold the applicator in an upright position with your face turned away, and break its tip by bending and folding into itself, For easy application, let your dog stand up. You can reapply after a month, but never use more than one applicator within 30 days [3, 4]. Activyl Tick Plus for Dogs. Use the entire content by squeezing the applicator firmly but avoid applying an excess amount at a particular spot, Indoxacarb (Activyl® Spot-On) for Dogs and Cats –, Evaluation of indoxacarb and fipronil (s)-methoprene topical spot-on formulations to control flea populations in naturally infested dogs and cats in private residences in Tampa FL. Now What?! For small dogs, apply at two spots, one between the shoulder blades and another above the tail, while for puppies and toy dogs, just one spot application would be enough. In some countries, this medicine may only be approved for veterinary use. As a general rule, dogs and cats tolerate topically applied indoxacarb very well. Treatment consists in preventing further exposure together with. Activyl® is a spot-on (topical) flea treatment for dogs and cats. The good news is that roach poisons are not nearly as toxic to dogs as they are to roaches. 26 This effect is suspected to be due to a metabolite of indoxacarb, N-hydroxylarylamine, which causes oxidative damage to red blood cells. Activyl Topical for Dogs and Cats are topical products that use indoxacarb and a mode of action that uses enzymes inside the flea to activate serious flea-killing power. It can have a mild toxic effect with dogs, even when it … All rights reserved. A recent study showed that flea infestation in pets could be effectively controlled by a single application of Activyl [5, 6]. What kind of bones are safe for dogs to chew or eat? However, things may not b… Required fields are marked *. Ingredient matches for Activyl for Small Dogs 6.6 up to 10kg Indoxacarb. Indoxacarb residue was found in the gloves in insignificant amounts until day 21 (0.65 ± 0.45 µg/g). Excretion is mainly through the feces. Birds / Cats / Dogs / ... but in many cases other non-toxic methods that are safe for your dog … If you have someone else in the home with you, get them … Let me tell you that Indoxacarb have a good affect on insect larvae,and it is safe for natural enemy insects. For medium and large dogs, apply the content evenly at 2-4 spots along your dog’s back, at different sites between its shoulder blades and the base of its tail [7]. Avoid grooming, stroking, bathing or shampooing your dog for 2 days after the treatment until the medication dries off completely [6]. It breaks down quickly when exposed to sunlight. WHO Acute Hazard classification of pesticides: II, moderately hazardous. There are a few instances where Activyl may cause adverse reactions, including: These effects are rare, and even when they occur, they usually disappear within a few hours to days without treatment [8]. Since your dog barely got a tooth on the bait you have nothing to worry about. This chemical is produced by DuPontand marketed in the U.S. as StewardTM, AvauntTM, and Technical IndoxacarbTM. After topical administration, indoxacarb remains mainly on the hair coat and skin of the treated pets. If irritation or symptoms persist, consult a doctor or contact poison control center for advice [9]. In case of accidental exposure, immediately rinse eyes with water or wash your skin with soap and water. Can dog get sore muscles? You need to get the right size applicator according to how big your dog is. It blocks the movements of sodium ions in certain nerve cells, which results in paralysis and death of the affected insects. In toxicity studies in dogs, indoxacarb induced Heinz bodies and hemolytic anemia when administered orally at 18-19 mg/kg/day. Activyl is used for prevention and treatment of parasitic attacks and the management of allergic dermatitis (allergic reactions) associated with flea and tick bites. The MSDS sheets list: Indoxacarb is one of these newer toxins. So, when the susceptible insect comes in contact with the medicine, its brain, and ventral nerve cord stop functioning, eventually killing it [2, 3]. Is it OK to diffuse peppermint oil around dogs? water dispersible granule (WG) proposed for use on apples, pears, Brassica, sweet corn, lettuce and fruiting Common Precautions. Eliminate Over 99% of Fleas with Activyl ® Topical for Dogs and Cats.. Activyl ® Topical for Dogs and Cats (indoxacarb) is a flea treatment that is highly effective at killing fleas and preventing infestation. Certain enzymes in the fleas’ body activate the indoxacarb in the medication, which then interferes with their spinal cord and brain, finally causing death. Flea season. As soon as the flea bites the dog, it absorbs Indoxacarb, which when reaching the flea’s gut, … Activyl for Dogs should not be used on cats. As per the recommendation of EPA (Environment Protection Agency), Indoxacarb is categorized as a “reduced-risk” pesticide that … To reduce exposure after spot-on treatment wash affected animals thoroughly with abundant lukewarm water and soap to remove the chemicals from the animal's hair coat. Apart from cats, indoxacarb is also safe for dogs. Talk to the vet if your dog or puppy has any known allergic reaction to any drugs, or if it is already receiving any medications or supplements [3]. Indoxacarb is the active ingredient in the new pet product, Activyl from Merck Animal Health. At what age do dogs stop getting vaccines? Indoxacarb and permethrin should never be used on cats, as it can be fatal. Monthly spot-on tick and flea treatment [4], Activyl Tick Plus: Indoxacarb, Permethrin [7], Prescription medication registered for veterinary use [3], Activyl Spot-On: Cats and kittens, dogs and puppies [1]. Be sure to follow dosage as instructed by the vet and read the label directions before use. Your email address will not be published. The type of indoxacarb formulation. The fast-acting topical solution starts killing fleas and ticks within 8 hours of applying, remaining effective for 30 days [4]. The normal dose is 15 mg/kg or 0.077 ml/kg of your dog’s body weight [8]. All information in this site is made available in good faith and following a reasonable effort to ensure its correctness and actuality. Mild anemia and slightly reduced weight gains were recorded at the highest doses. Perhaps, you may assume that what can kill ants, must somehow harm dogs. We get these questions very often, and the good news is that these traps have a small mount of product (the Indoxacab isn't toxic in small amounts to the dog) and also something 'yummy' to attract the ants such as peanut butter, breadcrumbs, sugar and oils which are attracting to pets. 1,2 Find out more about Activyl or Activyl Protector Band for Dogs to find the right fit for your pet. The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. To highly toxic to mammals if taken in large quanity s skin a wettable granule soluble. The liver to inactive metabolites considered a suitable, `` low-toxicity '' synthetic... The medication contains 195mg of indoxacarb, N-hydroxylarylamine, which results in paralysis and of! The inside of quite a few baits made available in good faith and a. Suitable, `` low-toxicity '', synthetic organophosphate replacement an ant bait, you obviously! 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